The role of salivary gland scintigraphy in the evaluation. Salivary gland scintigraphy or salivagram is a nuclear medicine scan used to show the function of the salivary glands. Salivary gland scintigraphy with 99mtcpertechnetate. This is a functional method that allows for the simultaneous evaluation of major salivary gland parenchyma and function. Provided, therefore, that the proper indications are observed, a. Part i 284 salivary gland scintigraphy salivary gland scintigraphy mwj versleijen, antoni van leeuwenhoek, amsterdam 1. The effect of radiotherapy on parotid gland function was studied by salivary scintigraphy in patients irradiated with different doses of radiation in the head and neck region. The scan is also a useful way to demonstrate blockages and certain types of tumor in the major salivary glands. Moreover, salivary gland scintigraphy is easy to perform, reproducible and welltolerated by the patient. Pertechnetate uptake in sublingual and minor salivary glands of the oral cavity was not visualized, thereby invalidating scintigraphy in the study of these glands.
In patients with chronic obstructive parotitis, 99mtcpertechnetate salivary gland scintigraphy showed reduced excretion by the affected glands. Salivary gland scintiscanning an overview sciencedirect. Histopathologic grade 1 or 2 was found in 29 patients and grade 3 or 4 was found in 41 patients, and they were regarded as being in the early and advanced stages of sjogrens syndrome, respectively. The role of salivary gland scintigraphy in the evaluation of. The uptake of pertechnetate in the glandular tissue and in a reference area in the neck are measured. Ultrasonography of salivary glands in primary sjogrens syndrome. Aanbevelingen nucleaire geneeskunde 2007, international.
Salivary gland scintigraphy is useful for differentiating salivary gland tumors because warthins tumors and. The diagnostic value of technetium 99m pertechnetate salivary. Pdf salivary gland scintigraphy in gastroesophageal. The chemicals in spit saliva can sometimes crystallise into a stone that can then block the salivary ducts. Pdf quantitative salivary gland scintigraphy researchgate. This guideline is based on available scientific literature on the subject, the previous guideline. Improved quantification of salivary gland scintigraphy by. Evaluation of salivary gland scintigraphy, magnetic resonance. The role of salivary gland scintigraphy in the evaluation of salivary gland dysfunction in uncontrolled type ii diabetic patients b senthilkumar 1, s sathasivasubramanian 2 1 department of oral medicine and radiology, k. Salivary gland scintigraphy of an untreated rabbit upper row and of a rabbit treated with 200 mgkg amifostine lower row before and 6 mo after application of 2 gbq 1 i. Salivary gland scintigraphy used to show abnormal salivary function in patients with symptoms such as dry mouth, bad breath and may be associated with a sensation of dry gritty eyes. Submandibular sialolithiasis with ct and scintigraphy. However, no standardized protocol for an accurate quantification of parenchymal function has been established so far.
Pdf does salivary gland scintigraphy predict response to. All slices were carefully examined and then graded by an experienced pathologist. Sensitivity and specificity of imaging modalities for sjogrens syndrome. Jan 15, 2021 salivary glands typically function without issue, but a blockage or infection within the salivary glands can cause significant pain and discomfort. Salivary gland scintigraphy in sjogrens syndrome and. Salivary gland scintigraphy is a sensitive and valid method for evaluation of the function of the salivary glands. Nevertheless, salivary gland scintigraphy with 99mtcpertechnetate still remains the only procedure with which the functional status of all major salivary glands can be studied simultaneously and as such it may offer information not obtainable by any other diagnostic technique. The fine anatomical and histological details will be covered in other courses.
Evaluation of diagnostic parameters from parotid and. No significant dependence on cumulative treatment was found for objective xerostomia or xerophthalmia, but doses 11. Sequential salivary gland scintigraphy with 99m tc. However, you should know the locations and characteristics of the salivary glands. Salivary gland scintigraphic data were gathered with a gammacamera with a lowenergy general purpose collimator. Approach to diagnosis of salivary gland disease from nuclear. After intravenous administration of 99mtc sodium pertechnetate, dynamic scintigraphy was performed. R institute of dental science and research, trichengode, namakkal district, tamil nadu, india 2 department of oral medicine and radiology, sri ramachandra dental college. The authors analysed, using salivary gland scintigraphy, the changes in salivary gland uptake and excretion in 90 patients before and 5 to 14 months mean 7.
Salivary gland anatomy n parotid gland n submandibular gland n sublingual gland n minor glands it is not our intent to cover anatomy during this course. Labial salivary gland biopsy 14 is a reliable and useful method for diagnosing sjs. Abnormal salivary function can be seen in patients with symptoms such as dry mouth, bad breath and may be associated with a sensation of dry gritty eyes. Salivary gland scintigraphy in sjogrens syndrome home thieme. Scintigraphy results correlate with clinical and histopathological features of the salivary glands in patients with ss. Some people form one or more small stones in a salivary gland.
Sg function was quantified by determining salivary flow rates sfr and using scintigraphic parameters for the submandibular and parotid glands. Regarding the salivary gland excretion fraction using salivary gland scintigraphy, the data were digitally gathered and plotted on separate timeactivity curves for the submandibular glands, and the rois of each submandibular gland were drawn manually. We have investigated the relationship between major salivary gland flow rates and tc. Pdf improved quantification of salivary gland scintigraphy. After intravenous 99mtcsodium pertechnectate administration, sequential head. Salivary scintigraphy has been useful for investigation of multiple diseases affecting the salivary glands. Forty patients with thyroid carcinoma, men age range, 2180 years. The diagnostic validity of salivary gland scintigraphy in sjogrens syndrome ss has not been conclusively defined. In recent years salivary gland scintigraphy has gained widespread acceptance as a useful means for evaluating. Introduction the selective uptake, accumulation and secretion of 99mtc pertechnetate by the salivary glands allow the function of the parotid and submandibular glands to. In this study the automatic separation of oral and salivary gland activity and spontaneous secretion by means of factor analysis for quantitative salivary gland scintigraphy is introduced. The validity of salivary gland scintigraphy in sjogrens. May 01, 2006 on the other hand, dynamic scintigraphy is still the method of choice in functional evaluation of the salivary glands, 10, 11. Plain film imaging plain film imaging helps in demonstrating presence of.
Quantitative salivary gland scintigraphy is demonstrated to be a suitable imaging modality for research applications in evaluating the effects of radioprotective drugs on salivary glands. Salivary gland scintigraphy with 99mtc sodium pertechnetate is an easy and noninvasive method to evaluate both parotid and submandibular glands for diagnosis and evaluation of sjogrens syndrome 25. Oct 19, 2020 the diagnostic validity of salivary gland scintigraphy in sjogrens syndrome ss has not been conclusively defined. Methods in this paper we report on a validated acquisition protocol supplying a normal database for standardized quantitative salivary gland scintigraphy. To compare an ultrasonographic us scoring system of salivary glands with scintigraphy and salivary gland biopsy, in order to evaluate its diagnostic value in primary sjogrens syndrome ss. Study of quantitative oral radioactivity in salivary gland. This was a pilot study of nine patients and as, after detailed analysis, we saw no difference between responders and nonresponders, it was decided that there was no. We sought to determine whether the diagnostic discrimination of excretion fraction is higher compared to that obtained by. Plain film radiography is indicated in the cases of obstruction of salivary gland causing symptoms like pain and. Psychological tests medical outcomes study short form general health. Scintigraphy ofthe salivary glands in sjogens syndrome. Summary scintigraphy of the salivary glands with technetiumsodium pertechnetate 99mtc was undertaken on 320 patients with oral dryness or connective. Scoring analysis of salivary gland scintigraphy in patients. Salivary gland scintigraphy may not be sufficiently sensitive to detect these small changes in salivary gland excretion which may be associated with subjective improvement.
Semiquantitative evaluation of salivary gland function in. Dynamic sgs dsgs can provide valuable information on the function and morphology of salivary glands and has been used for more than 40 years, for ss and various other salivary glands pathologies 1518. Introduction the selective uptake, accumulation and secretion of 99mtc pertechnetate by the salivary glands allow the function of the parotid and submandibular glands to be assessed. Salivary gland function was estimated by salivary gland scintigraphy by using 185mbq 5 mci technetium tc99m pertechnetate. The results indicate that quantitative salivary gland scintigraphy may be a useful method for evaluating salivary gland dysfunction and also for determining disease severity in primary ss. The salivary gland excretion fraction was defined as a before stimulation test.
Conclusion quantitative salivary gland scintigraphy is demonstrated to be a suitable imaging modality for research applications in evaluating the effects of radioprotective drugs on salivary glands. Can quantified salivary gland scintigraphy results aid. Average counts in the regions of interest rois in the right and the left salivary glands and the. This ensures that saliva evenly coats the inner lining of the mouth.
Chapter 5 sequential salivary gland scintigraphy using technetium99m and carbachol. In this article, we present the anatomy of the major salivary glands and neighboring structures as seen at us, as well as the us features of the most common pathologic conditions affecting the parotid and submandibular glands. Sialendoscopy is comparatively recent advancement that helps with diagnostic as well as interventional endoscopy of salivary glands. Salivary gland scintigraphy in patients with sjogrens syndrome. On the other hand, the saxon test,5 chewing gum test,6 and salivary gland scintigraphy are equally useful alternative non. Salivary gland scintigraphya suitable substitute for sialography. Pdf uptake of 99mtcpertechnetate in salivary glands reflects intact salivary gland parenchyma.
Quantitative evaluation of salivary gland scintigraphy in sjogrens. Dynamic salivary gland scintigraphy started immediately after the i. Objective uptake of 99mtcpertechnetate in salivary glands reflects intact salivary gland parenchyma. Salivary glands definition, function and location biology. Salivary gland scintigraphy has been widely accepted as a sensitive and valid method for evaluation of the function of the salivary glands. In 5 patients with suspected ss, the grades of 5 us measures of both parotid and submandibular salivary glands were scored 048 scale. Developed by renowned radiologists in each specialty, statdx provides comprehensive decision support you can rely on salivary gland scintigraphy. It is typically performed in a hospital nuclear medicine department or outpatient radiology facility.
Quantitative salivary gland scintigraphy can distinguish patients with primary sjogrens syndrome during the evaluation of sicca symptoms. Scintigraphy can be used in the functional evaluation of the gland. The minor salivary glands are not surrounded by a capsule but are embedded within the connective tissue. You will receive an injection of a lowlevel radioactive marker and will be positioned in front of or under a gamma scintillation camera, which detects. Diagnostic value of salivary gland ultrasonographic. Several studies for comparing the quantitative characteristics of salivary gland scintigraphy with the histopathologic grading. Scintigraphic evaluation of salivary gland function in.
Scintigraphy of the salivary glands in sjogens syndrome journal of. All of the patients underwent preoperative 99mtcpertechnetate salivary gland scintigraphy. The diagnostic value of technetium 99m pertechnetate. Pdf salivary gland scintigraphy in gastroesophageal reflux. The tumors can arise in about 80% in parotid gland, 15% in submandibular gland and 5% in the sublingual and minor salivary gland. Salivary gland scintigraphy sgs using 99mtc pertechnetate is a safe and noninvasive method that provides detailed functional assessment of. They found that decreased secretion velocity in the parotid gland and decreased accumulation in the submandibular gland were sensitive indicators of salivary gland disease in. The uptake of pertechnetate in the glandular tissue and in. The biopsy material was fixed in formaldehyde, embedded in paraffin, serially sliced, and stained by hematoxylineosin. This occurs most commonly in people between the ages of 30 and 60 years, although it can occur at any age.
Salivary gland scintigraphy is easy to perform, reproducible and welltolerated by the patient. May 07, 2017 nuclear medicine images can help in the diagnosis and assessment of some salivary disorders. A new and rapid method of quantitative salivary gland scintigraphy has been developed. Ultrasound can also be used to demonstrate abnormal salivary gland architecture, with the benefit of being noninvasive. Scintigraphic assessment of salivary gland function in a rat model. Compared with clinical and histological data, scintigraphy provides a sensitive method, even though it is not specific, for detecting minimal injuries to salivary glands in patients suspected ofhaving sj6gens syndrome.
Differential diagnosis of xerostomia by quantitative salivary gland scintigraphy. Salivary gland scintigraphy in sjogrens syndrome and patients with sicca symptoms but without sjogrens syndrome. Evaluation of salivary gland scintigraphy, magnetic. Diagnostic value of salivary gland ultrasonographic scoring. The function of the sublingual glands and the minor. In numerous studies, dsgs protocols and parameters of saliva accumulation and. Labial salivary gland biopsy the minor salivary glands of the lower lip were routinely sectioned following the informed consent. Salivary gland scintigraphy journal of nuclear medicine technology. A comparative study of salivary gland ultrasound, scintigraphy and salivary gland biopsy in 107 adult patients demonstrated that ultrasound was highly accurate as a diagnostic test, with 90. The salivary gland scan, also called parotid gland scintigraphy, is a noninvasive test. Salivary gland scintigraphy salivary gland scintigraphy mwj versleijen, antoni van leeuwenhoek, amsterdam 1. Quantitative analysis of 99mtcpertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. Scoring analysis of salivary gland scintigraphy in. In this article, we present the anatomy of the major salivary glands and neighboring structures as seen at us, as well as the us features of the most common pathologic conditions affecting the parotid and.
On the other hand, one patient had only submandibular gland involvement in the 99m tcpertechnetate scan. Differential diagnosis of xerostomia by quantitative. Salivary gland hypofunction in elderly patients with. Parotid scintigraphy the main indication of salivary scintigraphy is the assessment of salivary gland function in patients with dry mouth. However, its relationship to salivary function has not been investigated in detail. Origin and location of oral activity in sequential salivary gland scintigraphy with 99tcpertechnetate. Salivary gland scintigraphy was also performed on 21 healthy subjects with no evidence of salivary gland malfunction. The salivary glands are located in several areas around the mouth and have ducts connected to both the upper and lower jaw. Sjogrens syndrome, pertechnetate imaging can gauge. The aim of this study was to compare the diagnostic utility of visual versus semi quantitative analysis of salivary gland scinti. Salivary gland stones salivary calculi health patient. The purpose of this study was to evaluate differential dose of radiation effects on the parotid glands using quantitative salivary gland scintigraphy qsgs.
Approach to diagnosis of salivary gland disease from. Focal sialadenitis in sjogrens syndrome ss is associated with a decreased resting salivary flow of salivary gland scintigraphy results. Salivary gland imaging techniques for the diagnosis of. In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was tested.
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